Angiotensin Converting Enzyme, CSF
Use
Angiotensin Converting Enzyme (ACE) is used to diagnose and monitor diseases associated with the renin-angiotensin-aldosterone system, such as sarcoidosis. Elevated ACE is frequently found in cases of active pulmonary sarcoidosis. In cerebrospinal fluid (CSF), elevated ACE levels can indicate neurosarcoidosis; however, it has a limited diagnostic utility as high levels may also be present due to other conditions.
Special Instructions
Ensure that CSF submitted for testing does not contain gadolinium-based contrast agents, as these can inhibit ACE activity and compromise test results. The sample must be sent frozen to maintain integrity.
Limitations
The test for ACE in CSF has limited diagnostic utility due to overlap with other non-specific conditions that can similarly elevate ACE levels. Results should be interpreted in the context of clinical findings and other diagnostic procedures. This assay should not be the sole basis for diagnosing or managing sarcoidosis or other related conditions.
New York Approved
Methodology
Automated Analyzer (Clinical Chemistry)
Biomarkers
LOINC Codes
- 12480-0
- 12480-0
Result Turnaround Time
1-7 days
Related Documents
For more information, please review the documents below
Specimen
Cerebrospinal Fluid
Volume
1 mL
Minimum Volume
0.5 mL
Container
Sterile vial
Collection Instructions
Transfer 1 mL of spinal fluid to a sterile vial. Send frozen. Avoid CSF containing gadolinium-based contrast agents as they inhibit ACE activity.
Causes for Rejection
Hemolysis, xanthochromic specimens, specimens containing gadolinium-based contrast agents.
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 7 days |
| Frozen | 180 days |