Anti-Mi-2 Ab
Use
The Anti-Mi-2 test measures the presence of antibodies against Mi-2, a nuclear antigen associated with dermatomyositis, an inflammatory myopathy. Detection of these antibodies can be important in diagnosing and managing dermatomyositis, as they are found in a subset of patients suffering from this condition. The presence of Anti-Mi-2 antibodies is associated with a specific subset of dermatomyositis that might present distinct clinical features, thus aiding in more tailored patient care.
Special Instructions
The test is named 'Anti-Mi-2 Ab' and can also be searched using the aliases FFMI2, MI2, or Anti-Mi-2. The specimen should be collected using a red top tube (preferred) or serum gel tube (acceptable), with 1 mL of serum required for the test. It is vital to centrifuge and aliquot the serum into a plastic vial within one hour of collection. The sample must be refrigerated to ensure stability for up to 14 days, with alternative ambient stability for 7 days and frozen stability for 60 days.
Limitations
This test has not been cleared or approved by the FDA, impacting its usage in certain regulatory environments. Gross hemolysis, lipemia, icterus, bacterial contamination, or specimens other than serum can lead to specimen rejection, thus highlighting the importance of stringent sample handling and preparation. Repeat testing is not possible with the minimum volume as it allows only one testing attempt, necessitating accurate initial collection.
New York Approved
Methodology
Other
Biomarkers
LOINC Codes
- 18485-3
- 18485-3
Result Turnaround Time
16-25 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
Plastic vial
Collection Instructions
Within 1 hour of collection, centrifuge and aliquot 1 mL of serum into a plastic vial. Send refrigerate.
Storage Instructions
Refrigerated (preferred) for 14 days, Ambient for 7 days, Frozen for 60 days
Causes for Rejection
Gross hemolysis, Gross lipemia, Gross icterus, Specimens other than serum, Bacterial contamination
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 7 days |
| Refrigerated | 14 days |
| Frozen | 60 days |