Anti-Synthetase Profile
Use
The Anti-Synthetase Profile is used to detect antibodies associated with anti-synthetase syndrome, an autoimmune disease that can lead to interstitial lung disease (ILD), non-erosive arthritis, myositis, Raynaud’s phenomenon, unexplained fever, and/or mechanic’s hands. By identifying the presence of specific antibodies such as Anti-Jo-1, PL-7, PL-12, EJ, and OJ, this profile assists in diagnosing and managing autoimmune conditions.
Special Instructions
For this test, a 3 mL serum sample should be collected in a red-top tube and submitted in a plastic vial. Serum separator tubes are acceptable but not preferred. Ensure that specimens are kept refrigerated during transport and handling.
Limitations
This test has not been cleared or approved by the Food and Drug Administration and is not classified as a companion diagnostic. Performance characteristics were determined by LabCorp, and while analytically valid, results should be interpreted in conjunction with clinical findings. Gross hemolysis, lipemia, icterus, or contamination can result in specimen rejection.
New York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 35333-4
- 33772-5
- 33771-7
- 45149-2
- 45152-6
Result Turnaround Time
16-25 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
3 mL
Minimum Volume
1 mL
Container
Plastic vial
Collection Instructions
Draw blood in a plain red-top tube(s), serum gel tube is acceptable. Spin down and send 3 mL of serum refrigerated in a plastic vial.
Causes for Rejection
Gross hemolysis, gross lipemia, gross icterus, anything other than serum, bacterial contamination
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 7 days |
| Refrigerated | 14 days |
| Frozen | 60 days |