Antimullerian Hormone, Serum
Use
Antimullerian hormone (AMH), also known as Mullerian-inhibiting substance, is a dimeric glycoprotein important for assessing ovarian status, including ovarian reserve and responsiveness, particularly in the context of infertility and assisted reproduction. It is also involved in the assessment of menopausal status, evaluation of ambiguous genitalia in infants, and testicular function in children. Monitoring AMH levels is critical in individuals with AMH-secreting ovarian granulosa cell tumors and can serve as a marker for ovarian granulosa cell tumors, comprising 10% of ovarian tumors. Additionally, AMH measurement is useful in evaluating disorders of sexual development and male fertility conditions.
Special Instructions
If not ordering electronically, complete, print, and send a General Request form with the specimen. Ensure blood samples are centrifuged and serum aliquoted into a plastic vial for submission.
Limitations
AMH immunoassays can vary and non-standardized values between different assay methods cannot be used interchangeably. Drugs such as Cetrotide, Ovitrelle, Endometrin, and follistatin may interfere with this test. Biotin concentrations up to 1200 ng/mL do not interfere with the assay. Antibodies to animal antibodies or streptavidin may cause interference. Results should be interpreted alongside clinical findings. High-dose AMH concentrations (up to 1400 ng/mL) do not result in a hook effect in the assay, and the presence of interfering substances or improper collection can affect results.
New York Approved
Methodology
Immunoassay (ECLIA)
Biomarkers
LOINC Codes
- 83104-0
- 83104-0
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.75 mL
Container
Plastic vial
Collection Instructions
Centrifuge and aliquot serum into plastic vial.
Causes for Rejection
Gross hemolysis; acceptable to 1000 mg/dL. Gross icterus; acceptable to 66 mg/dL.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 7 days |
| Refrigerated | 7 days |
| Frozen | 180 days |