Apolipoprotein A1 and B, Serum
Use
This test is useful for assessing cardiovascular risk by providing levels of Apolipoprotein A1 and B, both of which are critical components of the lipoprotein structures. Apolipoprotein B is the main protein in low-density lipoproteins (LDL), commonly known as bad cholesterol, linked with the buildup of atherosclerotic plaques. Conversely, Apolipoprotein A1 is the main protein in high-density lipoproteins (HDL), referred to as good cholesterol, which helps remove cholesterol from the bloodstream. A balance measured through this test helps to evaluate the risk of cardiovascular disease even more accurately than traditional lipid panels, especially in individuals with a significant family history of coronary artery disease or those with lipid measures that do not correlate with clinical presentations.
Special Instructions
If not ordering electronically, complete, print, and send a Cardiovascular Test Request Form (T724) with the specimen. Ensure collection by centrifuging and aliquoting serum into a plastic vial. Specimen handling is crucial as gross hemolysis and icterus can lead to rejection.
Limitations
In rare cases, diagnostic confusion may occur, especially in patients with gammopathy such as Waldenstrom macroglobulinemia, which can lead to unreliable results. The test's performance characteristics are also contingent on adherence to collection and handling protocols, as improper specimen can result in unassessable outcomes. Additionally, extremely low or high values may need further clinical correlatives to rule out genetic or other pathological conditions.
FDA ApprovedNew York Approved
Methodology
Immunoassay (Turbidimetric Immunoassay)
Biomarkers
LOINC Codes
- 55724-9
- 1884-6
- 1869-7
- 1874-7
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
Plastic vial
Collection Instructions
Centrifuge and aliquot serum into a plastic vial.
Causes for Rejection
Gross hemolysis, Gross icterus
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 24 hours |
| Refrigerated | 8 days |
| Frozen | 60 days |