Arsenic Speciation, 24 Hour, Urine
Use
Used for diagnosing arsenic intoxication by measuring various arsenic species in a 24-hour urine specimen. Inorganic arsenic (As[III], As[V]) and their methylated metabolites (MMA, DMA) are toxic and summed as 'toxic arsenic'; organic forms (e.g., arsenobetaine, arsenocholine) are nontoxic and commonly from food sources such as seafood. Toxic arsenic reference value is <35 µg/L (per ACGIH BEI).([mayocliniclabs.com](https://www.mayocliniclabs.com/test-catalog/Overview/609383?utm_source=openai))
Special Instructions
Not provided.
Limitations
Seafood ingestion prior to collection may elevate organic arsenic levels, potentially confounding interpretation. Gadolinium and iodine contrast agents may interfere with ICP‑MS testing, necessitating delayed specimen collection.([mayocliniclabs.com](https://www.mayocliniclabs.com/test-catalog/Overview/609383?utm_source=openai))
New York Approved
Methodology
Mass Spectrometry (LC-MS/MS)
Biomarkers
LOINC Codes
- 96253-0 - Arsenic fractions Pnl 24h Ur
- 41992-9 - Inorg Arsenic 24h Ur-mCnc
- 96252-2 - Arsenic.methylated 24h Ur-mCnc
- 43181-7 - Arsenic organic 24h Ur-mCnc
- 96251-4 - Arsenic.inorganic+methylated 24h Ur-mCnc
- 21074-0 - Arsenic 24h Ur-mCnc
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Urine
Volume
10 mL
Minimum Volume
3 mL
Container
Clean, plastic urine collection container; plastic 10‑mL tube or clean plastic aliquot container with no metal cap or glued insert
Collection Instructions
Collect urine for 24 hours; refrigerate within 4 hours of completion; patient should refrain from seafood for 48 h prior and during collection; delay if gadolinium/iodine contrast within prior 96 h
Patient Preparation
Avoid seafood for 48 h before and during collection; if gadolinium‑ or iodine‑based contrast given, wait 96 h before collection
Causes for Rejection
Specimens evaluated for suitability; interference from contrast media or improper collection may result in rejection
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |
| Refrigerated | 28 days |
| Frozen | 28 days |