Aspergillus (Galactomannan) Antigen, Serum
Use
The Aspergillus (Galactomannan) Antigen test is useful for aiding in the diagnosis of invasive aspergillosis, a severe infection often occurring in patients with prolonged neutropenia, post-transplantation, or on aggressive immunosuppressive regimens. The test detects galactomannan, a molecule found in the cell wall of Aspergillus species, in the serum. This serologic assay can detect the presence of the antigen a mean of 7 to 14 days before other diagnostic indications appear, allowing for potential initiation of preemptive antifungal therapy.
Special Instructions
Avoid environmental contamination of the specimen. Send the specimen in the original serum gel tube, and do not aliquot or open the tube.
Limitations
False-positive results may occur at rates of 8% to 14%. Cross-reactivity has been reported with other fungi such as Penicillium and Paecilomyces. Foods containing galactomannan and certain medications can also affect results. The performance of the assay has not been evaluated for neonate serum specimens or non-serum specimens like plasma or urine.
FDA ApprovedNew York Approved
Methodology
Immunoassay (EIA)
Biomarkers
LOINC Codes
- 44357-2
- 44357-2
Result Turnaround Time
1-4 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1.5 mL
Minimum Volume
1 mL
Container
Serum gel tube
Collection Instructions
Avoid exposure of specimen to atmosphere to prevent sample contamination from the environment. Centrifuge and send specimen in original tube. Do not aliquot or open tube.
Storage Instructions
Refrigerated (preferred) or frozen for up to 14 days in a serum gel tube.
Causes for Rejection
Gross hemolysis, Gross lipemia
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 14 days |
| Frozen | 14 days |