B-Cell Acute Lymphoblastic Leukemia/Lymphoma (ALL), Specified FISH, Varies
Use
This test is useful for detecting recurrent common chromosome abnormalities associated with B-cell acute lymphoblastic leukemia/lymphoma (B-ALL/LBL) and Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) using client-specified probe set(s). It serves as an adjunct to conventional chromosome studies in patients with B-ALL/LBL and is used for evaluating specimens in which chromosome studies are unsuccessful. Additionally, this test helps in identifying and tracking known chromosome abnormalities in patients with B-ALL and monitoring response to therapy.
Special Instructions
Not provided.
Limitations
This test should not be used to screen for residual B-ALL/LBL. It is not approved by the US FDA and is intended as an adjunct to clinical and pathologic information. FISH is not a substitute for conventional chromosome studies because it detects only chromosome abnormalities targeted by the B-ALL panel or selected probes. Bone marrow is the preferred specimen type. If bone marrow is not available, blood specimen with neoplastic cells may be used.
New York Approved
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
LOINC Codes
- 102099-9 - B-cell ALL Bld/T FISH
- 50397-9 - Mol dx interp Bld/T Ql
- 69965-2 - Clinical cytogeneticist review
- 93356-4 - Cells w cytogenetic abnl Bld/T
- 62356-1 - Chrom analy result (ISCN)
- 42349-1
- 78040-3 - FISH probe target gene Lab Device
- 31208-2 - Specimen source
- 85069-3 - Lab test method
- 48767-8 - Annotation comment Imp
- 62364-5 - Test performance info Spec
- 18771-6 - Provider signing name
Result Turnaround Time
7-10 days
Related Documents
For more information, please review the documents below
Specimen
Bone Marrow
Volume
2 to 3 mL
Minimum Volume
1 mL
Container
Yellow top (ACD); Acceptable: Green top (sodium heparin) or lavender top (EDTA)
Collection Instructions
It is preferable to send the first aspirate from the bone marrow collection. Invert several times to mix bone marrow. Send bone marrow specimen in original tube. Do not aliquot.
Causes for Rejection
Fresh tissue
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Ambient (preferred) |
| Refrigerated | Refrigerated |