Beta-2 Glycoprotein 1 Antibodies, IgG and IgM, Serum
Use
This test is useful for evaluating patients with suspected antiphospholipid syndrome by identifying the presence of beta-2 glycoprotein 1 IgM and IgG antibodies. It serves as a first-line test when antiphospholipid syndrome is strongly suspected, often used in conjunction with cardiolipin antibodies (IgG and IgM) and lupus anticoagulant testing. It helps in estimating the risk of thrombosis and/or pregnancy-related morbidity in patients with systemic lupus erythematosus.
Special Instructions
Not provided.
Limitations
Immunoassays for detecting antiphospholipid antibodies, including beta-2 glycoprotein 1, may not completely distinguish between autoantibodies specific for antiphospholipid syndrome and those antibodies produced in response to infectious agents. Results from different commercial immunoassays may vary; hence documentation of persistence is crucial. Factors such as type of antiphospholipid antibody, antibody class, and level influence test interpretation and relevance.
New York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
Beta-2 Glycoprotein 1 IgG
ProteinBeta-2 Glycoprotein 1 IgM
Protein
LOINC Codes
- 72488-0 - B2 glycoprot 1 IgG+IgM pnl Ser
- 44448-9 - B2 Glycoprot1 IgG SerPl IA-aCnc
- 44449-7 - B2 Glycoprot1 IgM SerPl IA-aCnc
Result Turnaround Time
2-6 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.4 mL
Container
Plastic vial
Collection Instructions
Centrifuge and aliquot serum into a plastic vial.
Causes for Rejection
Gross hemolysis, gross lipemia, heat-treated specimens
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 21 days |
| Frozen | 21 days |