Beta-2-Microglobulin (Beta-2-M), Spinal Fluid
Use
Beta-2-microglobulin (beta-2-M) is a small membrane protein associated with the heavy chains of class I major histocompatibility complex proteins and is present on the surface of all nucleated cells. Its small size allows beta-2-M to pass through the glomerular membrane; however, it is almost completely reabsorbed in the proximal tubules. Elevated beta-2-M levels in the cerebrospinal fluid (CSF) can be diagnostic in cases of non-Hodgkin lymphoma with central nervous system involvement. Increased CSF:serum ratios are observed in conditions such as aseptic meningoencephalitis, indicating possible neurologic processes including those associated with HIV infection and acute lymphoblastic leukemia. In the context of multiple sclerosis, the significance of beta-2-M measurement remains indeterminate.
Special Instructions
Not provided.
Limitations
The results from assays using different manufacturers or methods may not be directly comparable due to potential variations in antibody-antigen interactions or other factors affecting assay performance. This test, while valuable in certain diagnostic scenarios, should not be used in isolation for the diagnosis or management of multiple sclerosis or for evaluating general inflammatory processes in the central nervous system.
New York Approved
Methodology
Immunoassay (Nephelometry)
Biomarkers
LOINC Codes
- 1951-3 - B2 Microglob CSF-mCnc
- 1951-3 - B2 Microglob CSF-mCnc
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Cerebrospinal Fluid
Volume
1 mL
Minimum Volume
0.5 mL
Container
Sterile vial
Collection Instructions
Send spinal fluid from collection vial 1.
Causes for Rejection
Gross hemolysis - OK
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 28 days |
| Frozen | 28 days |