Bleeding Diathesis Profile, Limited, Plasma
Use
Detection of the more common potential causes of abnormal bleeding such as factor deficiencies (hemophilia), von Willebrand disease, and factor-specific inhibitors. It provides a simple screen to evaluate for an inhibitor or severe deficiency of factor XIII, which is rare. Useful for differential diagnosis in patients with unexplained bleeding issues.
Special Instructions
Important to note if the patient is receiving anticoagulant or fibrinolytic therapy, as this can lead to false-positive results. Also, the study should ideally be performed pretransfusion or after an appropriate waiting period post-transfusion to avoid any interference.
Limitations
This test is not useful for assessing platelet function, which requires fresh platelets. Factors such as gross hemolysis, lipemia, and icterus can result in specimen rejection, highlighting the need for careful specimen handling.
New York Approved
Methodology
Other
Biomarkers
LOINC Codes
- 3209-4
- 3241-7
- 3187-2
- 27816-8
- 14979-9
- 48664-7
- 46717-5
- 18771-6
- 69049-5
- 6301-6
- 5902-2
- 68324-3
Result Turnaround Time
7-21 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
6 mL in 6 plastic vials, each containing 1 mL
Minimum Volume
4 plastic vials, each containing 1 mL
Container
Light-blue top (3.2% sodium citrate)
Collection Instructions
Centrifuge, transfer all plasma into a plastic vial, and centrifuge plasma again. Aliquot plasma (1-2 mL per aliquot) into 6 separate plastic vials, leaving 0.25 mL in the bottom of centrifuged vial. Freeze plasma immediately at -20 degrees C or, ideally, -40 degrees C or below.
Patient Preparation
Patient should not be receiving anticoagulant (e.g., warfarin, heparin) or fibrinolytic agents (streptokinase, urokinase, tPA). The study should be conducted pretransfusion or after 48 hours if recently transfused.
Storage Instructions
Freeze at -20 degrees C or, ideally, -40 degrees C or below.
Causes for Rejection
Gross hemolysis, gross lipemia, gross icterus
Stability Requirements
| Temperature | Period |
|---|---|
| Frozen | 14 days |