Bone Alkaline Phosphatase, Serum
Use
The Bone Alkaline Phosphatase (BAP) test is useful for diagnosing and assessing the severity of metabolic bone diseases such as Paget disease, osteomalacia, and other conditions with high bone turnover. It is also used to monitor the efficacy of antiresorptive therapies, including treatments for postmenopausal osteoporosis. BAP is the bone-specific isoform of alkaline phosphatase and serves as a sensitive indicator of bone metabolism, reflecting the activity of osteoblasts, which are bone-forming cells.
Special Instructions
The test is not intended as a screening tool for osteoporosis. Measurements of bone turnover markers are not useful for diagnosing osteoporosis; diagnosis should be based on bone density.
Limitations
Assay results should be considered alongside other diagnostic evaluations, as antibodies like HAMA or heterophile antibodies may interfere with some immunoassays. Liver-derived alkaline phosphatase may also interfere with this assay by yielding elevated results due to cross-reactivity.
FDA ApprovedNew York Approved
Methodology
Immunoassay (Immunoenzymatic Assay)
Biomarkers
LOINC Codes
- 17838-4
- 17838-4
Result Turnaround Time
2-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.6 mL
Minimum Volume
0.5 mL
Container
Plastic vial
Collection Instructions
Centrifuge and aliquot serum into a plastic vial.
Causes for Rejection
Gross hemolysis
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 7 days |
| Refrigerated | 14 days |
| Frozen | 90 days |