C-Reactive Protein (CRP) Immunostain, Technical Component Only
Use
C-reactive protein (CRP) is an acute-phase reactant associated with host defense that promotes agglutination and complement fixation. It is used with a panel of immunohistochemical markers to distinguish hepatic adenoma from focal nodular hyperplasia and non-neoplastic liver. CRP, along with amyloid A, is overexpressed in inflammatory (type 3) hepatic adenoma and may stain hepatocytes in nonneoplastic liver tissue in areas of nonspecific inflammation.
Special Instructions
Not provided.
Limitations
This test does not include a pathologist's interpretation, and the results should be evaluated in the context of the patient's clinical history by a qualified pathologist. Age of the paraffin section can affect immunoreactivity. Consistency in slide staining may be affected by environmental factors such as humidity and charge of glass slides, which emphasizes the importance of adhering to best practices for slide storage.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
C-reactive protein
Protein
LOINC Codes
- Order only;no result
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Immunostain Technical Only Envelope
Collection Instructions
Formalin-fixed, paraffin-embedded tissue block or 2 unstained, positively charged glass slides (25- x 75- x 1-mm) per test ordered; sections 4-microns thick.
Causes for Rejection
Wet/frozen tissue, cytology smears, nonformalin fixed tissue, nonparaffin embedded tissue, noncharged slides, ProbeOn slides, Snowcoat slides.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Ambient (preferred) |