Cadmium/Creatinine Ratio, Random, Urine
Use
Detecting exposure to cadmium, a toxic heavy metal, using random urine specimens. Cadmium toxicity primarily affects the kidney and manifests after chronic exposure, with early changes in proximal tubule function detectable via cadmium excretion relative to creatinine. Urine cadmium levels above 3.0 µg/g creatinine indicate significant exposure, and OSHA guidelines for occupational monitoring suggest less than 3.0 µg/g creatinine, with a biological exposure index at 5 µg/g creatinine.
Special Instructions
Specimen must not be collected for 96 hours if gadolinium- or iodine-containing contrast media have been administered. Collect a random urine specimen using a clean, plastic urine container with no metal cap or glued insert. See 'Metals Analysis Specimen Collection and Transport' for complete instructions.
Limitations
Collection through a catheter may result in elevated values due to cadmium leaching from rubber. All specimens are evaluated for suitability; any interferents (e.g., contrast media, metal contamination) may invalidate the specimen.
New York Approved
Methodology
Mass Spectrometry (LC‑MS/MS)
Biomarkers
LOINC Codes
- 13471-8
- 2161-8
- 13471-8
Result Turnaround Time
2-4 days
Related Documents
For more information, please review the documents below
Specimen
Urine
Volume
3 mL
Minimum Volume
1.5 mL
Container
Clean, plastic urine container with no metal cap or glued insert; Submission container: plastic, 10‑mL urine tube or clean, plastic aliquot container with no metal cap or glued insert
Collection Instructions
Collect a random urine specimen; patient should not have gadolinium- or iodine-containing contrast media administered within prior 96 hours.
Patient Preparation
Avoid collection within 96 hours of gadolinium- or iodine-containing contrast media administration.
Causes for Rejection
Specimens assessed for suitability; catheter-collected specimens may lead to elevated results due to rubber contamination.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 28 days |
| Frozen | 28 days |