Calponin Immunostain, Technical Component Only
Use
This test is a marker for myoepithelium, aiding in the differentiation of ductal carcinomas in situ from infiltrating breast carcinoma. It is also useful in the characterization of tumors of smooth muscle or myoepithelial lineage. Calponin is a cytoskeleton-associated protein involved in smooth muscle contraction, expressed in smooth muscle cells of blood vessels and myoepithelial cells in normal human breast tissue.
Special Instructions
Not provided.
Limitations
This test does not include pathologist interpretation. External factors affecting positively charged glass slides can alter staining. Slides should be minimally stored after unpackaging, with limited exposure to high humidity and heat. Age can affect immunoreactivity, particularly in paraffin sections cut over six weeks prior.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
Calponin
Protein
LOINC Codes
- Order only;no result
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Immunostain Technical Only Envelope
Collection Instructions
Attach the green pathology address label and the pink Immunostain Technical Only label included in the kit to the outside of the transport container.
Storage Instructions
Best practices for storage of positively charged slides include minimizing storage time and exposure to humidity and heat.
Causes for Rejection
Wet/frozen tissue, cytology smears, non-formalin fixed tissue, non-paraffin embedded tissue, noncharged slides, ProbeOn slides, Snowcoat slides
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Preferred |