CD123 Immunostain, Technical Component Only
Use
CD123 Immunostaining is useful as a marker for plasmacytoid dendritic cells, mast cells, and megakaryocytes. It also plays a crucial role in distinguishing blastic plasmacytoid dendritic cell neoplasm from acute monocytic leukemia. The CD123 antigen, part of the IL3 receptor complex, is involved in cellular growth and differentiation. This test assists in identifying increased numbers of plasmacytoid monocytes in conditions like Kikuchi lymphadenitis, helping in diagnostic processes.
Special Instructions
Not provided.
Limitations
The test does not provide a pathologist interpretation, only the technical component of the stain. Age of the paraffin section and environmental factors affecting glass slide charge can affect staining consistency. Paraffin sections are best cut within 6 weeks for optimal results. Non-compatible sample types like wet/frozen tissue and non-positively charged slides may result in rejection. CD123 expression can also vary across certain conditions and literature, highlighting the importance of paired clinical history and diagnostic information for correct interpretation.
FDA ApprovedNew York Approved
Methodology
Immunoassay (IHC)
Biomarkers
CD123
Protein
LOINC Codes
- Order only;no result
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Immunostain Technical Only Envelope
Causes for Rejection
Wet/frozen tissue, cytology smears, nonformalin fixed tissue, nonparaffin embedded tissue, noncharged slides, ProbeOn slides, Snowcoat slides
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Ambient (preferred) |