Central Nervous System Consultation, Autopsy, Varies
Use
This test provides comprehensive evaluation and diagnosis of complex neurological conditions through detailed neuropathological examination. It is particularly useful for the investigation of congenital neurological diseases, neurodegenerative conditions, cases with intricate neurological or neurosurgical histories, and unexplained deaths. The service includes neuropathologist consultation, careful dissection, and necessary diagnostic staining, aiding in uncovering unusual or rare neuropathological cases.
Special Instructions
Ensure all relevant clinical information, operative notes, and radiographs accompany the specimen. Use the Central Nervous System Consult Kit (T633) for shipping. This test is not intended for cases under litigation without preauthorization.
Limitations
Evaluation is limited to the specimens provided. Results depend on the quality and completeness of clinical and specimen data submitted. Specimens must be fully fixed in formalin for 7 to 10 days prior to shipping for proper diagnostics. Critically inadequate specimen preservation or incomplete clinical information may hinder interpretation.
New York Approved
Methodology
Other
Biomarkers
LOINC Codes
- 18743-5
- 18743-5
- 19139-5
- 35265-8
- 22634-0
- 22633-2
- 62364-5
- 80398-1
Result Turnaround Time
30-60 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
1 cm(3) cube
Minimum Volume
Entire collection
Container
Plastic container
Collection Instructions
1. Take a small (1 cm[3]) cube of brain from one of the frontal lobes (typically, right inferior frontal). 2. Wrap in aluminum foil and place in plastic container. 3. Label container with identifying information (i.e., patient name, date of birth, autopsy number, and date of collection). 4. Freeze and store in a -70 degrees C freezer. 5. Place the remaining brain in 10% formalin if non-Creutzfeldt-Jakob disease (CJD), and 15% formalin for suspected cases of CJD, suspended by a thread under the basilar artery and fixed for 7 to 10 days.
Storage Instructions
Freeze and store in a -70 degrees C freezer.
Causes for Rejection
No specimen should be rejected.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Ambient (preferred) |