Cholesterol, High-Density Lipoprotein (HDL), Serum
Use
Measurement of serum high-density lipoprotein concentrations is useful for managing the risk of atherosclerotic cardiovascular disease. High-density lipoprotein cholesterol (HDL-C) is associated with a lower risk of cardiovascular disease as it facilitates the reverse cholesterol transport. This test is often ordered along with total cholesterol to calculate non-HDL cholesterol, which is directly associated with cardiovascular disease risk.
Special Instructions
If not ordering electronically, complete, print, and send the cardiovascular test request form with the specimen. Fasting for 8 hours is preferred for sample collection but not mandatory unless explicitly directed by the ordering provider.
Limitations
The results can be falsely reduced in the presence of elevated levels of N-acetyl-p-benzoquinone imine (NAPQI), N-acetylcysteine (NAC), and metamizole. Extremely low HDL values may indicate liver disease or inherited dyslipidemia, and medications to increase HDL levels have failed to reduce cardiovascular disease.
FDA ApprovedNew York Approved
Methodology
Automated Analyzer (Clinical Chemistry)
Biomarkers
LOINC Codes
- 2085-9
- 2085-9
Result Turnaround Time
1 day
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.25 mL
Container
Plastic vial
Collection Instructions
Serum gel tube must be centrifuged within 2 hours of collection. Red-top tube must be centrifuged, and the serum aliquoted into a plastic vial within 2 hours of collection.
Patient Preparation
Fasting: 8 hours, preferred but not required unless directed by the ordering provider.
Causes for Rejection
Gross hemolysis
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 7 days |
| Frozen | 30 days |