Chromium Occupational Exposure, Random, Urine
Use
Screening for occupational exposure to chromium, particularly hexavalent chromium (Cr⁶⁺), via measurement of chromium in random urine specimens. This assists in monitoring potential workplace exposure to chromium compounds and evaluating elevated levels above physiologic baseline.
Special Instructions
When gadolinium- or iodine‑containing contrast media has been administered, specimen collection should not occur for 96 hours due to interference with ICP‑MS. Uses clean, plastic urine collection container with no metal cap or glued insert; refer to "Metals Analysis Specimen Collection and Transport" for complete instructions.
Limitations
Normal urine levels of chromium are very low; elevated results may result from external contamination. Metal‑free urine collection procedures must be followed. Refrigeration is preferred over chemical preservation. Interference may occur if contrast agents containing gadolinium or iodine were administered within 96 hours prior to collection.
New York Approved
Methodology
Mass Spectrometry (LC-MS/MS)
Biomarkers
LOINC Codes
- 13464-3
- 13464-3
- 2161-8
- 5623-4
Result Turnaround Time
2-8 days
Related Documents
For more information, please review the documents below
Specimen
Urine
Volume
3 mL
Minimum Volume
2 mL
Container
Clean, plastic urine collection container with no metal cap or glued insert; submission in plastic 5‑mL tube or clean plastic aliquot container with no metal cap or glued insert
Collection Instructions
Collect a random urine specimen; if gadolinium‑ or iodine‑containing contrast media administered, delay collection for 96 hours; refer to Metals Analysis Specimen Collection and Transport for complete instructions
Patient Preparation
Avoid collection if gadolinium‑ or iodine contrast media administered within 96 hours
Storage Instructions
Refrigerate preferred; ambient or frozen acceptable per stability
Causes for Rejection
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 28 days |
| Frozen | 28 days |