Chromosome Analysis, Hematologic Disorders, Blood
Use
Chromosomal abnormalities are crucial in the diagnosis and monitoring of hematologic disorders. Chromosome analysis of blood is useful when bone marrow is unavailable, assisting in classifying and following up on certain malignant hematologic disorders. Chromosomal abnormalities can indicate a neoplastic process, and increased genetic complexity identified through studies can be associated with clinical outcomes such as treatment response and survival rates.
Special Instructions
When ordering, provide a reason for testing to ensure accurate testing and interpretation. Notify the lab if the patient is on a Children's Oncology Group protocol to ensure the correct test is ordered. For chronic lymphocytic leukemia or related conditions, CpG-stimulated culture and additional analysis are added for patients 30 years or older.
Limitations
The test may not detect subtle chromosomal abnormalities or abnormalities without circulating abnormal cells. B-cell proliferation in cultures can be challenging due to poor proliferation without mitogens. Using CpG as a mitogen stimulates B-cell growth, helping detect chromosomal abnormalities. Technical factors like improper collection or transportation can affect test accuracy.
New York Approved
Methodology
Chromosomal / Cytogenetics (Karyotype)
Biomarkers
LOINC Codes
- 62348-8
- 50397-9
- 69965-2
- 82939-0
- 42349-1
- 31208-2
- 85069-3
- 62359-5
- 48767-8
- 18771-6
Result Turnaround Time
9-11 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
6 mL
Minimum Volume
3 mL
Container
Yellow top (ACD); Acceptable: Green top (sodium heparin) or lavender top (EDTA)
Collection Instructions
Invert several times to mix blood. Send whole blood specimen in original tube. Do not aliquot.
Storage Instructions
Ambient temperature preferred; Refrigerated acceptable.
Causes for Rejection
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.