Chronic Inflammatory Demyelinating Polyradiculoneuropathy/Nodopathy Evaluation, Serum
Use
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an acquired, immune-mediated condition affecting peripheral nerves and nerve roots. It is characterized by electrodiagnostic features of demyelination with a chronic onset, leading to significant disability. CIDP is important to recognize due to its treatability with appropriate immunomodulating therapies, despite being a rarer cause of polyneuropathy. Autoantibodies target nodal-paranodal proteins, with the neurofascin-155 and contactin-1 complex being common targets. Disruption of this interaction has been linked to demyelination, and the presence of these antibodies helps in diagnosing and differentiating CIDP from other neuropathies.
Special Instructions
Not provided.
Limitations
A negative result does not exclude the presence of immune-mediated demyelinating neuropathy. The test's sensitivity may be compromised if immunotherapy has been administered prior to sample collection. Furthermore, it should only be utilized within the appropriate clinical context to ensure accurate diagnosis.
New York Approved
Methodology
Cell-based / Cytometry
Biomarkers
LOINC Codes
- 101447-1 - CASPR1 IgG + NF155 IgG4 pnl SerPl
- 100845-7 - Neurofascin155 IgG4 Ser Ql FC
- 69048-7 - Immunologist review
- 101448-9 - CASPR1 IgG SerPl Ql CBA IFA
Result Turnaround Time
5-10 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
3 mL
Minimum Volume
2 mL
Container
Red top (preferred), serum gel (acceptable), Plastic vial (submission container)
Collection Instructions
Centrifuge and aliquot serum into a plastic vial.
Patient Preparation
For optimal antibody detection, collect the specimen before starting immunosuppressant or intravenous immunoglobulin treatment.
Storage Instructions
Refrigerated for up to 28 days, ambient for 72 hours, or frozen for up to 28 days.
Causes for Rejection
Gross hemolysis, gross lipemia, gross icterus
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |
| Refrigerated | 28 days |
| Frozen | 28 days |