Clobazam and Metabolite, Serum
Use
Clobazam is a broad spectrum, antiepileptic drug used for various types of seizures, Lennox-Gastaut syndrome (a type of childhood onset epilepsy), and migraine prophylaxis. Monitoring clobazam therapy is important because serum concentrations influence the drug's efficacy and potential side effects. Clobazam blocks voltage-dependent sodium channels, potentiates gamma-aminobutyric acid (GABA) activity at some of the GABA receptors, and inhibits potentiation of the glutamate receptor and carbonic anhydrase enzyme.
Special Instructions
Trough specimens are recommended as therapeutic ranges are based on specimens collected at trough, which is immediately before the next dose.
Limitations
Interpretation should include clinical evaluation. Most individuals may show optimal response within specific serum levels, but some might respond well outside these ranges or display toxicity within therapeutic range limits. Patients with impaired kidney function may exhibit decreased clearance and prolonged elimination half-life. Concurrent use of other medications such as phenytoin, carbamazepine, posaconazole, or phenobarbital requires dose adjustment of clobazam and therapeutic drug monitoring.
New York Approved
Methodology
Mass Spectrometry (LC-MS/MS)
Biomarkers
LOINC Codes
- 79408-1
- 3487-6
- 35107-2
Result Turnaround Time
1-5 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.35 mL
Container
Red top (serum gel/SST are not acceptable)
Collection Instructions
Collect blood immediately before next scheduled dose. Within 2 hours of collection centrifuge and aliquot serum into a plastic vial.
Causes for Rejection
None
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 28 days |
| Refrigerated | 28 days |
| Frozen | 28 days |