Cocaine and Metabolites Confirmation, Meconium
Use
Detecting in utero drug exposure up to 5 months before birth. Intrauterine drug exposure to cocaine has been associated with placental abruption, premature labor, small for gestational age status, microcephaly, and congenital anomalies such as cardiac and genitourinary abnormalities and central nervous system stroke or hemorrhage. The presence of drugs in meconium indicates in utero drug exposure during the last 4 to 5 months of pregnancy, providing a longer historical measure than urinalysis.
Special Instructions
For chain-of-custody testing, order COKMX / Cocaine and Metabolite Confirmation, Chain of Custody, Meconium. Complete and send a Therapeutics Test Request Form (T831) with the specimen if not ordering electronically.
Limitations
No significant cautionary statements were noted. It is important to ensure proper specimen collection and handling as well as appropriate test selection to avoid diagnostic confusion.
New York Approved
Methodology
Mass Spectrometry (LC-MS/MS)
Biomarkers
LOINC Codes
- 69008-1
- 69009-9
- 69010-7
- 69011-5
- 69012-3
- 69050-3
- 77202-0
Result Turnaround Time
2-3 days
Related Documents
For more information, please review the documents below
Specimen
Other
Volume
1 g (approximately 1 teaspoon)
Minimum Volume
0.3 g (approximately 1/4 teaspoon)
Container
Stool container, Small (Random), 4 oz (T288)
Collection Instructions
Collect entire random meconium specimen.
Causes for Rejection
Grossly bloody specimens; stool in diapers is rejected.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |
| Refrigerated | 21 days |
| Frozen | 21 days |