Collagenofibrotic Glomerulopathy Confirmation, Mass Spectrometry
Use
Collagenofibrotic glomerulopathy (CG), also called collagen type III glomerulopathy, is a rare kidney disease characterized by large amounts of atypical type III collagen fibrils in the mesangium and subendothelial space of renal glomeruli. Liquid chromatography tandem mass spectrometry performed on microdissected glomeruli from patients with CG demonstrates a unique proteomic profile. The presence of type III collagen, in the appropriate clinical and pathological context, can be useful to establish a diagnosis of CG.
Special Instructions
Not provided.
Limitations
Improper specimen collection, handling, inappropriate test selection, and interfering substances may cause diagnostic confusion. Testing can only be done on paraffin-embedded tissue blocks. Do not send fixed tissue slides.
New York Approved
Methodology
Mass Spectrometry (LC-MS/MS)
Biomarkers
Type III Collagen
Protein
LOINC Codes
- 65757-7 - Kidney Path Bx report
- 50595-8 - Path Interp Spec-Imp
- 19139-5 - Pathologist name
- 81178-6 - Block description and site Spec
- 62364-5 - Test performance info Spec
- 80398-1 - Unique ID Current sample
- 22634-0 - Path report.gross Spec
- 35265-8 - Path Report.addendum Spec
Result Turnaround Time
7-15 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
Do not send fixed tissue slides. Testing can only be done on paraffin-embedded tissue blocks.
Causes for Rejection
Fixed tissue slides, wet/frozen tissue, cytological smears, nonformalin fixed tissue, nonparaffin embedded tissue