Collapsin Response-Mediator Protein-5-IgG, Western Blot, Serum
Use
Autoantibodies specific for neurons and muscle are important serological markers of neurological autoimmunity. CRMP-5 is highly expressed in small-cell lung carcinomas, neurons, and a subset of glial cells. CRMP-5-IgG, known as anti-CV-2, often accompanies SCLC and sometimes occurs with thymomas. It can present multifocally in patients, affecting various levels of the neuraxis and is associated with neurological syndromes suggesting CRMP-5-IgG relevance.
Special Instructions
Not provided.
Limitations
CRMP-5-IgG may not be detectable by standard IF screening if titers are low or if coexisting autoantibodies impede identification. Seronegativity does not exclude the presence of a neoplasm. Western blot analysis is advised if interfering autoantibodies prevent accurate detection of CRMP-5-IgG by indirect immunofluorescence assay.
New York Approved
Methodology
Immunoassay (Western Blot)
Biomarkers
CRMP-5-IgG
Protein
LOINC Codes
- 47401-5 - CV2 IgG Ser Ql IB
- 47401-5 - CV2 IgG Ser Ql IB
Result Turnaround Time
5-10 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1.5 mL
Minimum Volume
1 mL
Container
Plastic vial
Collection Instructions
Centrifuge and aliquot serum into a plastic vial.
Causes for Rejection
Gross hemolysis, Gross lipemia, Gross icterus
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |
| Refrigerated | 28 days |
| Frozen | 28 days |