Cryoglobulin and Cryofibrinogen Panel, Serum and Plasma
Use
The Cryoglobulin and Cryofibrinogen Panel is useful for evaluating patients with vasculitis, glomerulonephritis, and lymphoproliferative diseases. It is also helpful for patients with macroglobulinemia or myeloma who experience symptoms in cold exposure. The test is not recommended for general screening without a clinical suspicion of cryoglobulinemia.
Special Instructions
Not provided.
Limitations
Failure to follow specimen handling instructions may result in false-negative results. Analysis cannot be performed with less than 3 mL of serum, as smaller volumes are insufficient to detect clinically important trace cryoglobulins. Cryofibrinogen-positive specimens are not quantitated or immunotyped, and slowly forming fibrin clots must be distinguished from cryoprecipitates by their inability to redissolve on warming.
FDA ApprovedNew York Approved
Methodology
Other
Biomarkers
LOINC Codes
- 74352-6 - Cryoglob+cryofib Pnl Ser+Pl
- 11043-7 - Cryofib Plas Ql
- 12201-0 - Cryoglob Ser Ql 1D Cold Inc
Result Turnaround Time
2-10 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
1 mL
Minimum Volume
0.5 mL
Container
Plastic vial
Collection Instructions
Tube must remain at 37 degrees C. Centrifuge at 37 degrees C. Do not use a refrigerated centrifuge. Ensure that the specimen remains at 37 degrees C until after separation of plasma from red blood cells.
Patient Preparation
Fasting: 12 hours, preferred but not required