Desmoglein 1 (DSG1) and Desmoglein 3 (DSG3), IgG Antibodies, Serum

Casandra

Casandra Test Code MC18666Version 1 (DRAFT)

Performing Lab

Lab Mayo Clinic LabLab Test ID DSGABCPT Code 83516

Desmoglein 1 (DSG1) and Desmoglein 3 (DSG3), IgG Antibodies, Serum

Clinical Use

Use

Pemphigus includes a group of often fatal autoimmune blistering diseases characterized by intraepithelial lesions. Pemphigus vulgaris and its variants may present with oral or mucosal lesions alone or with mucosal plus skin lesions. Pemphigus foliaceous and variants present with skin lesions alone. Indirect immunofluorescence studies reveal that both forms of pemphigus are caused by autoantibodies to cell surface antigens of stratified epithelia or mucous membranes and skin. These antibodies bind to calcium-dependent adhesion molecules in cell surface desmosomes, notably desmoglein 1 (DSG1) in pemphigus foliaceus and desmoglein 3 (DSG3) or DSG1 in pemphigus vulgaris.

Special Instructions

Recommend repeat testing of indeterminate specimens, either with a fresh specimen collected at a later time or the original specimen tested by another method. The desmoglein 1 (DSG1) and desmoglein 3 (DSG3) results serve only as an aid to diagnosis and should not be interpreted as diagnostic by themselves. The results should be interpreted in conjunction with clinical evaluation of the patient along with other diagnostic procedures.

Limitations

Performance of these assays in the pediatric population has not been established. The assay performance characteristics have not been established for matrices other than serum. A positive result indicates the presence of antibodies to recombinant DSG1 and DSG3 and does not specifically identify a certain type of pemphigus. A negative result does not rule out the presence of pemphigus.

Test Details

New York Approved