Dihydrorhodamine Flow Cytometric Test, Blood

Use

The Dihydrorhodamine Flow Cytometric Test is primarily used for the evaluation of chronic granulomatous disease (CGD), both X-linked and autosomal recessive forms. It can identify Rac2 deficiency, monitor nicotinamide adenine dinucleotide phosphate oxidase (NOX) function post-hematopoietic cell transplantation, assess residual NOX activity pretransplant, and help identify female carriers of X-linked CGD. It also evaluates changes in lyonization with age in female carriers. Approximately 70% of CGD cases are due to mutations in the CYBB gene, while other cases involve mutations in genes like NCF1, NCF2, and CYBA.