Dilute Russell's Viper Venom Time (DRVVT) Interpretation
Use
Lupus anticoagulants (LA) are immunoglobulins of autoimmune type that target antigenic phospholipid complexes and coagulation-related proteins, causing prolongation of clotting time tests. The Dilute Russell's Viper Venom Time (DRVVT) test is used to interpret mixing and confirmation assays for lupus anticoagulants. DRVVT interpretation aids in diagnosing or excluding LA by assessing the screen and confirmatory ratios. It is used in conjunction with other tests to detect or rule out LA.
Special Instructions
Not orderable as a standalone test. For more information, refer to DRVI1 / Dilute Russell's Viper Venom Time (DRVVT), with Reflex, Plasma. Use the DRVVT screen, mix, and confirm ratios along with other coagulation tests to diagnose or exclude LA.
Limitations
The DRVVT test may not identify all lupus anticoagulants due to their heterogeneous nature. It cannot distinguish LA from certain factor inhibitors or heparin. Clinical correlation, and repeat testing remote from anticoagulation therapy, are advised. Proper specimen collection and handling are essential, as residual platelets or anticoagulant effects may impact the test's sensitivity and specificity.
New York Approved
Methodology
Other
Biomarkers
LOINC Codes
- 50008-2
- 50008-2
Result Turnaround Time
2 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
Not provided
Minimum Volume
Not provided
Container
Plasma Na Cit
Stability Requirements
| Temperature | Period |
|---|---|
| Frozen | 14 days |