Dilute Russell's Viper Venom Time (DRVVT) Mix, Plasma
Use
The DRVVT Mix test is useful for detecting the presence or helping to exclude lupus anticoagulants (LA), particularly those that do not prolong activated partial thromboplastin time (APTT). It is utilized in evaluating the unexplained prolongation of the APTT or prothrombin time clotting tests and distinguishing LA from specific coagulation factor inhibitors or deficiencies. It confirms abnormal dilute Russell's viper venom time ratios and is part of the reflexive testing for identifying LA.
Special Instructions
Not provided.
Limitations
False positives can occur due to anticoagulation therapy effects. Residual platelets in specimens can decrease sensitivity and specificity, leading to false negatives. The test may not detect all lupus anticoagulants; other tests like Staclot LA or APTT may be needed. LA diagnosis does not have definite predictive value for associated clinical complications. The presence of LA must be confirmed over time (at least 12 weeks) for reliable antiphospholipid syndrome diagnosis.
FDA ApprovedNew York Approved
Methodology
Immunoassay
Biomarkers
Lupus Anticoagulant
Analyte
LOINC Codes
- 75512-4 - Mixing dRVVT/normal
- 75512-4 - Mixing dRVVT/normal
Result Turnaround Time
2-5 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
Specimens must be centrifuged twice to remove platelets before freezing.
Storage Instructions
Keep frozen for up to 14 days.
Causes for Rejection
Gross hemolysis, gross lipemia, gross icterus
Stability Requirements
| Temperature | Period |
|---|---|
| Frozen | 14 days |