Duloxetine, Serum
Use
This test is useful for monitoring duloxetine serum concentration during therapy, evaluating potential duloxetine toxicity, and assessing patient compliance. Duloxetine is an antidepressant of the serotonin-norepinephrine reuptake inhibitor class, effective in treating symptoms of depression, including physical pain associated with depression. It is also used for neuropathic pain, fibromyalgia, and urinary stress incontinence. The test helps in understanding the potential for drug interactions and managing conditions related to serotonin uptake inhibition.
Special Instructions
Collect blood immediately before the next scheduled dose (trough). Within 2 hours of collection, centrifuge and aliquot serum into a plastic vial. Do not use serum gel/SST tubes for collection.
Limitations
Specimens obtained using gel tube or anticoagulant collections can cause falsely decreased results or assay interference. Duloxetine is not recommended for patients with hepatic impairment, substantial alcohol use, or chronic liver disease. Use in patients with kidney disease significantly increases exposure to duloxetine due to decreased elimination, so close monitoring is required.
New York Approved
Methodology
Mass Spectrometry (LC-MS/MS)
Biomarkers
LOINC Codes
- 46227-5
- 46227-5
Result Turnaround Time
1-8 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
Plastic vial
Collection Instructions
Draw blood immediately before the next scheduled dose (trough). Centrifuge and aliquot serum into a plastic vial within 2 hours of collection.
Causes for Rejection
Specimens obtained using gel tubes or anticoagulant collections can cause falsely decreased results or assay interference.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 28 days |
| Refrigerated | 28 days |
| Frozen | 28 days |