Estriol, Unconjugated, Serum
Use
This test is used as an adjunct biomarker in the prenatal diagnosis of disorders of fetal steroid metabolism, such as Smith-Lemli-Opitz syndrome and X-linked ichthyosis. It is also useful in evaluating primary or secondary fetal adrenal insufficiency after other rare single gene defects have been excluded, including aromatase deficiency, 17 alpha-hydroxylase deficiency, and various forms of congenital adrenal hyperplasia.
Special Instructions
Not provided.
Limitations
The test may be affected by the presence of antibodies to mouse or other animal antibodies, known as human anti-mouse antibodies (HAMA), which may cause interference in immunoassays. If results do not align with clinical presentation, further investigation may be required, including notifying the laboratory to retest or revalidate the assay performance.
FDA ApprovedNew York Approved
Methodology
Immunoassay (Immunoenzymatic Assay)
Biomarkers
Estriol, Unconjugated
Analyte
LOINC Codes
- 2250-9 - u Estriol SerPl-mCnc
- 2250-9 - u Estriol SerPl-mCnc
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.6 mL
Minimum Volume
0.5 mL
Container
Plastic vial, preferred collection container is red top tube or serum gel tube.
Collection Instructions
Centrifuge and aliquot serum into a plastic vial.
Causes for Rejection
Gross hemolysis
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 14 days |
| Frozen | 90 days |