Fatty Acid Profile, Comprehensive (C8-C26), Plasma
Use
This test is useful for monitoring patients undergoing diet therapy for mitochondrial or peroxisomal disorders, which might induce essential fatty acid deficiency due to restricted fat intake. It is also applicable for monitoring the treatment of essential fatty acid deficiency and the response to provocative tests like fasting or loading tests. The test provides a comprehensive profile regarding mitochondrial and peroxisomal fatty acid metabolism and the nutritional status of the patient.
Special Instructions
Not provided.
Limitations
For nutritional assessment, a 12-hour fasting period is required. However, prolonged fasting is contraindicated for patients with suspected fatty acid oxidation disorders. Improper specimen collection and handling, or inappropriate test selection, may lead to diagnostic confusion. Elevated levels of certain fatty acids may suggest fatty acid oxidation disorders or peroxisomal disorders. The test does not diagnose such conditions definitively, which may require further confirmatory testing.
New York Approved
Methodology
Mass Spectrometry (GC-MS)
Biomarkers
LOINC Codes
- 43674-1 - FA comp C8-C26 Pnl SerPl
- 35145-2 - Octanoate SerPl-sCnc
- 35147-8 - Decenoate SerPl-sCnc
- 35146-0 - Decanoate SerPl-sCnc
- 35151-0 - Lauroleate SerPl-sCnc
- 35150-2 - Laurate SerPl-sCnc
- 35148-6 - Tdecadienoate SerPl-sCnc
- 35158-5 - Myristoleate SerPl-sCnc
- 35157-7 - Myristate SerPl-sCnc
- 35154-4 - Hexadecadienoate SerPl-sCnc
- 35155-1 - Hexadecenoate SerPl-sCnc
- 35162-7 - Palmitoleate SerPl-sCnc
- 35161-9 - Palmitate SerPl-sCnc
- 35163-5 - G-Linolenate SerPl-sCnc
- 35164-3 - A-Linolenate SerPl-sCnc
- 35165-0 - Linoleate SerPl-sCnc
- 35166-8 - Oleate SerPl-sCnc
- 35167-6 - Vaccenate SerPl-sCnc
- 35149-4 - Octadecanoate SerPl-sCnc
- 35173-4 - EPA SerPl-sCnc
- 35168-4 - AA SerPl-sCnc
- 35172-6 - Mead acid SerPl-sCnc
- 35171-8 - Homo-G Linolenate SerPl-sCnc
- 35169-2 - Arachidate SerPl-sCnc
- 35174-2 - DHA SerPl-sCnc
- 35181-7 - Docosapentaenate w6 SerPl-sCnc
- 35180-9 - DPA SerPl-sCnc
- 35182-5 - Docosatetraenoate SerPl-sCnc
- 35160-1 - Docosenoate SerPl-sCnc
- 30194-5 - VLCFA C22:0 SerPl-sCnc
- 35170-0 - Nervonate SerPl-sCnc
- 30195-2 - VLCFA C24:0 SerPl-sCnc
- 33036-5 - VLCFA C26:1 SerPl-sCnc
- 30197-8 - VLCFA C26:0 SerPl-sCnc
- 22761-1 - Pristanate SerPl-sCnc
- 22671-2 - Phytanate SerPl-sCnc
- 35411-8 - Trienoate/AA SerPl-sRto
- 35175-9 - Sat FA SerPl-sCnc
- 35176-7 - Monounsat FA SerPl-sCnc
- 35177-5 - Polyunsat FA SerPl-sCnc
- 35178-3 - w3 FA SerPl-sCnc
- 35179-1 - w6 FA SerPl-sCnc
- 24461-6 - FA SerPl-sCnc
- 59462-2 - Clinical biochemist review
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
0.5 mL
Minimum Volume
0.15 mL
Container
Plastic vial
Collection Instructions
Centrifuge and aliquot plasma into a plastic vial.
Patient Preparation
Patient must fast for 12 hours, and not consume alcohol for 24 hours prior. For patients with suspected fatty acid oxidation disorder, collect as close to the patient's next scheduled meal as possible.
Causes for Rejection
Gross lipemia will cause rejection of the specimen.
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 72 hours |
| Frozen | 92 days |