FibroTest-ActiTest, Serum
Use
The FibroTest-ActiTest is utilized for evaluating hepatic fibrosis and inflammatory activity in patients with liver conditions such as chronic hepatitis C and B, HIV co-infection, and nonalcoholic fatty liver disease. It enables clinicians to assess the severity of hepatic fibrosis and necroinflammatory activity while providing access to treatment options for hepatitis. The test employs a combination of six serum biomarkers which provide a non-invasive alternative to liver biopsy, aiding in diagnosis and monitoring of liver fibrosis.
Special Instructions
Not provided.
Limitations
The FibroTest-ActiTest may produce inaccurate results in situations involving acute liver conditions, drug-induced enzyme changes, or when performed on patients under 2 years of age. Conditions such as acute hemolysis, hepatitis, inflammation, and specific drug interactions can alter the test's reliance on serum biomarkers. Elevated levels of individual biomarkers may signal caution or preclude accurate interpretation. The test is not suitable for patients under 2 years.
New York Approved
Methodology
Algorithm
Biomarkers
LOINC Codes
- 48796-7 - HCV FibroSURE Pnl SerPl
- 1975-2 - Bilirub SerPl-mCnc
- 1743-4 - ALT SerPl w P-5'-P-cCnc
- 1835-8 - A2 Macroglob SerPl-mCnc
- 1869-7 - Apo A-I SerPl-mCnc
- 2324-2 - GGT SerPl-cCnc
- 46127-7 - Haptoglob SerPl Neph-mCnc
- 48795-9 - Liver fibr score SerPl Calc.FibroSure
- 48794-2 - Fibrosis stage SerPl Ql
- 88447-8 - Liver fibrosis interpretation Ser-Imp
- 48792-6 - Necroinflammatory act score SerPl
- 48793-4 - Necroinflammatory act grade SerPl Ql
- 88448-6 - Necroinflammatory activ interp Ser-Imp
- 48767-8 - Annotation comment Imp
- 74715-4 - Serial #
Result Turnaround Time
2-5 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
3 mL
Minimum Volume
1.5 mL
Container
Amber vial
Collection Instructions
Centrifuge and aliquot serum into an amber vial within 2 hours of collection. Ensure specimen is light-protected within 4 hours of collection.
Patient Preparation
Age and sex are required.
Storage Instructions
Store refrigerated (preferred), frozen, or ambient, ensuring the specimen is light protected for defined durations.
Causes for Rejection
Gross hemolysis, gross lipemia, gross icterus, patients <2 years of age.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 24 hours |
| Refrigerated | 7 days |
| Frozen | 14 days |