FibroTest-ActiTest, Serum
Use
The FibroTest-ActiTest is utilized for evaluating hepatic fibrosis and inflammatory activity in patients with liver conditions such as chronic hepatitis C and B, HIV co-infection, and nonalcoholic fatty liver disease. It enables clinicians to assess the severity of hepatic fibrosis and necroinflammatory activity while providing access to treatment options for hepatitis. The test employs a combination of six serum biomarkers which provide a non-invasive alternative to liver biopsy, aiding in diagnosis and monitoring of liver fibrosis.
Special Instructions
Age and sex of the patient are required for accurate interpretation. The specimen should be maintained light-protected within 4 hours of collection, with specific handling instructions to centrifuge and aliquot serum into an amber vial promptly within 2 hours of collection. Caution is necessary in interpreting results under certain conditions such as acute hemolysis, hepatitis, and inflammation. Expert consultation is recommended particularly in cases of discordant biopsy results or unusual biochemical profiles.
Limitations
The FibroTest-ActiTest may produce inaccurate results in situations involving acute liver conditions, drug-induced enzyme changes, or when performed on patients under 2 years of age. Conditions such as acute hemolysis, hepatitis, inflammation, and specific drug interactions can alter the test's reliance on serum biomarkers. Elevated levels of individual biomarkers may signal caution or preclude accurate interpretation. The test is not suitable for patients under 2 years.
New York Approved
Methodology
Algorithm
Biomarkers
LOINC Codes
- 48796-7
- 1975-2
- 1743-4
- 1835-8
- 1869-7
- 2324-2
- 46127-7
- 48795-9
- 48794-2
- 88447-8
- 48792-6
- 48793-4
- 88448-6
- 48767-8
- 74715-4
Result Turnaround Time
2-5 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
3 mL
Minimum Volume
1.5 mL
Container
Amber vial
Collection Instructions
Centrifuge and aliquot serum into an amber vial within 2 hours of collection. Ensure specimen is light-protected within 4 hours of collection.
Patient Preparation
Age and sex are required.
Storage Instructions
Store refrigerated (preferred), frozen, or ambient, ensuring the specimen is light protected for defined durations.
Causes for Rejection
Gross hemolysis, gross lipemia, gross icterus, patients <2 years of age.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 24 hours |
| Refrigerated | 7 days |
| Frozen | 14 days |