Folate Receptor Alpha (FOLR1), Semi-Quantitative Immunohistochemistry, Manual
Use
Folate receptor 1 protein (FOLR1), also known as folate receptor alpha (FRa), is expressed in approximately 90% of ovarian carcinomas and serves as a predictive biomarker for FOLR1-targeted therapy for epithelial ovarian cancer. FOLR1 is a member of the folate receptor family that is reported to be highly expressed in various tumors of epithelial origin but has restricted expression in normal epithelial cells. Diagnosis of epithelial ovarian cancer that may be eligible for treatment with an anti-folate receptor 1 protein antibody.
Special Instructions
A pathology/diagnostic report and a brief history are required. This test may be utilized for all types of ovarian cancers. Send the specimen with the green 'Attention Pathology' address label (T498).
Limitations
This test has been validated for non-decalcified paraffin-embedded tissue specimens fixed in 10% neutral buffered formalin. Specimens are recommended to be placed in formalin within 1 hour of acquisition and fixed for 12 to 72 hours. Age and storage conditions of glass slides can affect immunoreactivity and staining. The test has not been validated on tissue subjected to alternative fixatives or decalcification.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
LOINC Codes
- 105010-3
- 50595-8
- 19139-5
- 81178-6
- 62364-5
- 80398-1
Result Turnaround Time
5-7 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Formalin-fixed, paraffin-embedded tissue block OR 3 unstained glass, 'positively-charged' glass slides
Collection Instructions
Send in a Pathology Packaging Kit (T554).
Storage Instructions
Ambient (preferred) or refrigerated.
Causes for Rejection
Wet/frozen tissue, decalcified paraffin embedded tissue, cytology smears, non-formalin fixed tissue, nonparaffin embedded tissue, noncharged slides, ProbeOn slides, Snowcoat slides.