Gamma-Hydroxybutyric Acid (GHB), Urine
Use
The purpose of this test is to detect the presence of gamma-hydroxybutyric acid (GHB) in urine samples. GHB is a central nervous system depressant that is used medically for anesthesia and treatment of narcolepsy, but it is also misused recreationally and known as a 'date rape' drug due to its sedative properties. Detecting GHB in urine helps to confirm exposure or ingestion, which is crucial for both clinical management and legal investigations.
Special Instructions
This test includes the initial screening for GHB, and if the result is non-negative, a confirmatory test (Gamma-Hydroxybutyric Acid, CF, UR) will be performed at an additional charge. It is important to collect the urine sample properly and store it as specified to ensure the test's accuracy.
Limitations
The detection of GHB in urine is time-sensitive since it is rapidly metabolized and eliminated from the body. The presence of GHB may also result from natural endogenous production but typically at much lower levels. False negatives can occur if the sample is not collected soon after administration or exposure, and high water intake may dilute the sample, impacting sensitivity.
New York Approved
Methodology
Mass Spectrometry (LC-MS/MS)
Biomarkers
LOINC Codes
- 29868-7
- 29868-7
Result Turnaround Time
5-9 days
Related Documents
For more information, please review the documents below
Specimen
Urine
Volume
10 mL
Minimum Volume
1.2 mL
Container
Plastic container
Collection Instructions
Collect 10 mL random urine without preservatives. Ship refrigerated.
Storage Instructions
Refrigerate preferred for up to 14 days. Stable ambient for 72 hours or frozen for 180 days.
Causes for Rejection
None specified
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |
| Refrigerated | 14 days |
| Frozen | 180 days |