GATA-Binding Protein 3 Immunostain, Technical Component Only, Bone Marrow
Use
GATA-binding protein 3 (GATA3) is a transcription factor involved in the regulation of development and differentiation of various human tissues such as T cells, skin, kidney, mammary gland, and the central nervous system. It is useful in the characterization of carcinomas, including primary bladder and breast carcinomas, and certain types of mesenchymal and neuroectodermal tumors, such as paragangliomas.
Special Instructions
Not provided.
Limitations
The test is optimized for B5-fixed, decalcified, paraffin-embedded bone marrow specimens. The age of a cut paraffin section can affect immunoreactivity, with stability thresholds widely varying depending on the antigen. Best practice recommends cutting paraffin sections within 6 weeks. This test does not include pathologist interpretation, thus requiring ordering of PATHC / Pathology Consultation for full diagnostic evaluation or second opinion.
FDA ApprovedNew York Approved
Methodology
Immunoassay (IHC)
Biomarkers
GATA3
Protein
LOINC Codes
- Order only;no result
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Immunostain Technical Only Envelope
Collection Instructions
Preferred: 2 Unstained positively charged glass slides (25- x 75- x 1-mm) per test ordered; sections 4-microns thick; B5 fixed, decalcified, paraffin-embedded bone marrow tissue. Acceptable: B5 fixed, decalcified, paraffin-embedded bone marrow tissue block.
Causes for Rejection
Wet/frozen tissue, Cytology smears, Nonformalin fixed tissue, Nonparaffin embedded tissue, Noncharged slides, ProbeOn slides
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Preferred ambient shipping conditions. |