Germinal Center B-cell Expressed Transcript 1 Immunostain, Technical Component Only
Use
Germinal center B-cell expressed transcript 1 (GCET1), also known as Centerin and SERPIN9, is expressed in B cells in the germinal center of normal lymph node and tonsil tissues. Most follicular lymphomas strongly express GCET1. A proportion of diffuse large B-cell lymphomas (DLBCL) are positive. In the diagnosis of B-cell lymphomas, GCET1 can be a useful marker in an immunohistochemical panel to assign a germinal center phenotype.
Special Instructions
Not provided.
Limitations
This test does not include pathologist interpretation, only the technical performance of the stain. If interpretation is required, order PATHC / Pathology Consultation for a full diagnostic evaluation or second opinion. The charge of glass slides can be affected by environmental factors, which may alter slide staining. Sending unsuitable slides can result in inconsistent staining due to poor surface chemistry. The age of paraffin sections can affect immunoreactivity; best practice is for sections to be cut within 6 weeks.
FDA ApprovedNew York Approved
Methodology
Immunoassay (IHC)
Biomarkers
GCET1
Protein
LOINC Codes
- Order only;no result
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Immunostain Technical Only Envelope
Causes for Rejection
Wet/frozen tissue, cytology smears, nonformalin fixed tissue, nonparaffin embedded tissue, noncharged slides, ProbeOn slides, Snowcoat slides