Germinal Center B-cell Expressed Transcript 1 Immunostain, Technical Component Only

Casandra

Casandra Test Code MC69129Version 1 (DRAFT)

Performing Lab

Lab Mayo Clinic LabLab Test ID GCETCPT Codes 88341, 88342

Germinal Center B-cell Expressed Transcript 1 Immunostain, Technical Component Only

Clinical Use

Use

Germinal center B-cell expressed transcript 1 (GCET1), also known as Centerin and SERPIN9, is expressed in B cells in the germinal center of normal lymph node and tonsil tissues. Most follicular lymphomas strongly express GCET1. A proportion of diffuse large B-cell lymphomas (DLBCL) are positive. In the diagnosis of B-cell lymphomas, GCET1 can be a useful marker in an immunohistochemical panel to assign a germinal center phenotype.

Special Instructions

This test includes only technical performance of the stain; no pathologist interpretation is provided. Technical component only stains should not be ordered with PATHC / Pathology Consultation. If ordered with PATHC, the technical component stains will be canceled. Shipping instructions require the use of specific labels and envelopes.

Limitations

This test does not include pathologist interpretation, only the technical performance of the stain. If interpretation is required, order PATHC / Pathology Consultation for a full diagnostic evaluation or second opinion. The charge of glass slides can be affected by environmental factors, which may alter slide staining. Sending unsuitable slides can result in inconsistent staining due to poor surface chemistry. The age of paraffin sections can affect immunoreactivity; best practice is for sections to be cut within 6 weeks.

Test Details

FDA Approved