Use

This test is useful for evaluating patients with clinical features of anti-glomerular basement disease, including rapidly progressive glomerulonephritis or pulmonary hemorrhage. Anti-glomerular basement (GBM) disease is a rare autoimmune disease associated with the presence of anti-GBM antibodies, particularly of the IgG isotype, which bind to the non-collagenous domain 1 (NC1) of the alpha3 chain of type IV collagen. These antibodies can trigger complement activation, leading to vascular necrosis and damage to the glomerular basement membrane. Evaluating the presence of these antibodies is crucial for diagnosing anti-GBM disease, particularly in patients with compatible clinical symptoms.