Glutathione, Blood
Use
The test is useful for evaluating conditions related to neonatal hyperbilirubinemia, chronic or episodic hemolysis, jaundice, gamma-glutamylcysteine synthetase deficiency, glutathione synthetase deficiency causing hemolytic anemia, and generalized glutathione synthetase deficiency with 5-oxoprolinuria. It is relevant for identifying enzyme deficiencies that may lead to glutathione deficiency, which can have clinical consequences such as hemolytic anemia and oxidative stress-related disorders.
Special Instructions
The test requires whole blood and should be sent in the original collection tube. Do not aliquot the sample. Complete and send a Benign Hematology Test Request form if not ordering electronically.
Limitations
Samples with high white blood cell counts may falsely elevate glutathione levels. Recent transfusions may mask intrinsic enzyme activity leading to unreliable results. Elevated GSH levels can be non-specific and may result from various conditions such as lead poisoning or dyserythropoietic disorders. Autosomal recessive inheritance patterns have been observed for enzyme deficiencies affecting GSH levels.
New York Approved
Methodology
Automated Analyzer (Clinical Chemistry)
Biomarkers
LOINC Codes
- 2383-8
- 2383-8
Result Turnaround Time
10-13 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
6 mL
Minimum Volume
1 mL
Container
Yellow top (ACD solution B)
Collection Instructions
Send whole blood specimen in original tube. Do not aliquot.
Causes for Rejection
Gross hemolysis, Frozen, Clotted (partial or whole)
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 20 days |