Gluten, IgE, Serum
Use
This test is useful for establishing a diagnosis of gluten allergy by identifying IgE antibodies specific to gluten and related proteins. It helps define the allergens responsible for allergic responses and symptoms and is especially relevant for confirming sensitization before starting immunotherapy. Additionally, it investigates the specificity of allergic reactions to various allergens including foods, drugs, and other agents.
Special Instructions
IgE antibody testing is not recommended for patients who have already undergone immunotherapy, as the test does not determine residual clinical sensitivity. Furthermore, it is not useful for cases where medical management does not rely on allergy specificity.
Limitations
Individuals may show measurable IgE antibody levels without significant clinical sensitivity, hence results should be interpreted in conjunction with clinical symptoms. Additionally, false positives may occur in cases of extremely high IgE levels due to nonspecific binding phenomena, which can make it challenging to accurately differentiate between specific allergies and general IgE elevations.
FDA ApprovedNew York Approved
Methodology
Immunoassay (FEIA)
Biomarkers
LOINC Codes
- 6125-9
- 6125-9
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL for every 5 allergens requested
Minimum Volume
For 1 allergen: 0.3 mL; For more than 1 allergen: (0.05 mL x number of allergens) + 0.25 mL deadspace
Container
Preferred: Serum gel; Acceptable: Red top; Submission: Plastic vial
Collection Instructions
Centrifuge and aliquot serum into a plastic vial.
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 14 days |
| Frozen | 90 days |