GRB2-Associated Binding Protein 1 (GAB1) Immunostain, Technical Component Only
Use
The GAB1 test is used for the identification and differentiation of medulloblastomas. Medulloblastomas are divided into molecular subgroups: SHH (sonic hedgehog), WNT (wingless-type murine mammary tumor), or non-SHH/WNT. GAB1 serves as an adapter protein in cell signaling pathways involved in growth, transformation, and apoptosis and can be part of a panel for immunohistochemical analysis to classify medulloblastomas into appropriate subgroups.
Special Instructions
Not provided.
Limitations
The test does not include pathologist interpretation, only technical performance of the stain is covered. Positive and negative controls will be verified but interpretation should be done in the context of the patient's clinical history or other diagnostic tests by a qualified pathologist. Additionally, environmental factors and the age of the paraffin section may affect immunoreactivity outcomes. Best practices include cutting paraffin sections within six weeks and properly storing charged slides to avoid inconsistent staining results.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
GAB1
Protein
LOINC Codes
- Order only;no result
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Immunostain Technical Only Envelope
Causes for Rejection
Wet/frozen tissue, cytology smears, nonformalin fixed tissue, nonparaffin embedded tissue, noncharged slides, ProbeOn slides, Snowcoat slides
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Ambient (preferred) |
| Refrigerated | Refrigerated |