Hematologic Disorders, Fluorescence In Situ Hybridization (FISH) Hold, Varies
Use
This test is designed to process bone marrow or peripheral blood specimens but delay the fluorescence in situ hybridization (FISH) analysis while the preliminary morphologic assessment is in process. It is useful in detecting common, recurrent chromosome abnormalities in most hematologic malignancies. If a specimen does not show evidence of malignancy, FISH analysis may not be necessary. In some cases, conventional chromosome analysis might be more informative.
Special Instructions
Upon specimen receipt, it will be held in the laboratory. FISH testing will not be performed unless the client contacts the Cytogenetics Laboratory by 4 p.m. CT within 4 business days after specimen collection. If no notification is received in time, the order will be canceled. Weekend communications can be deferred until Monday. This test does not apply to chromosome analysis; a different test is required if chromosome analysis is needed.
Limitations
This test is not applicable for chromosome analysis. Specimens must be held in conditions suitable for FISH analysis until the client provides instructions to proceed with testing. If FISH testing is not requested, the test will be reported as canceled, and only a processing fee may be assessed.
New York Approved
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
LOINC Codes
- 50397-9
- 69965-2
- 42349-1
- 31208-2
- 48767-8
- 85069-3
- 18771-6
Result Turnaround Time
4 days
Related Documents
For more information, please review the documents below
Specimen
Bone Marrow
Volume
2 to 3 mL
Minimum Volume
1 mL
Container
Yellow top (ACD); Acceptable: Green top (sodium heparin) or lavender top (EDTA)
Collection Instructions
It is preferable to send the first aspirate from the bone marrow collection. Invert several times to mix bone marrow. Send bone marrow in original tube. Do not aliquot.
Causes for Rejection
Fresh tissue: Reject
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Ambient (preferred) |