Hematopathology Consultation, MCL Embed
Use
This test is useful for obtaining a rapid, expert opinion for the diagnosis of hematologic and non-hematologic diseases using unprocessed bone marrow biopsy specimens referred by the primary pathologist. It also facilitates obtaining special studies that are not available locally. A full bone marrow workup is provided, which includes an evaluation of the specimen and a diagnosis provided within a formal pathology report. Ancillary testing, such as cytochemical stains, immunohistochemical stains, chromosome analysis, FISH, flow cytometry, microarray, molecular and/or next-generation sequencing, may be performed to assist in rendering an accurate diagnosis and provide important prognostic information.
Special Instructions
Laboratory approval is required prior to ordering this test. Contact Mayo Clinic Laboratories at 800-533-1710. When bone marrow aspirate volume is limited, the staff hematopathologist will prioritize testing. Tests requested by the referring physician may not be performed if deemed unnecessary by the reviewing staff hematopathologist. Calls are typically not made, but may be placed for cases such as acute leukemia or high-grade lymphoma.
Limitations
This test requires a comprehensive set of specimens and accompanying clinical information to make a diagnosis. All appropriate stained/unstained slides, biopsy tissue, and aspirate are necessary. Lack of this information may interfere with diagnosis. Improper specimen collection and handling, inappropriate test selection, and interfering substances can cause diagnostic confusion. Some tests ordered outside of this consultation may not be integrated into the final pathology report.
New York Approved
Methodology
Other
Biomarkers
LOINC Codes
- 78251-6
- 60570-9
- 19139-5
- 35265-8
- 22634-0
- 85298-8
- 62364-5
- 80398-1
Result Turnaround Time
3-7 days
Related Documents
For more information, please review the documents below
Specimen
Bone Marrow
Volume
5 slides
Minimum Volume
Not provided
Container
Plastic slide holder
Collection Instructions
Prepare slides of bone marrow aspirate. If bone marrow units are sparse or absent or aspirate is a dry tap, make biopsy touch prep slides. Air dry slides. Do not place on hot plate to dry. Place Parafilm around the slide carriers to prevent exposure to formalin fumes during transport. Place slides in a separate bag apart from any formalin-fixed clot or core biopsy specimens.