Hepatitis B Virus Core Total Antibodies, with Reflex to Hepatitis B Virus Core IgM Antibody, Serum
Use
This test is useful for the detection and differentiation of recent, past/resolved, or chronic hepatitis B virus (HBV) infections. It is particularly valuable for diagnosing recent HBV infection during the window period when both hepatitis B surface (HBs) antigen and anti-HBs are negative. The test is not useful for determining immunity to or recovery from HBV infection.
Special Instructions
The date of collection is required. For 24 hours before specimen collection, patients should not take multivitamins or dietary supplements containing biotin (vitamin B7). If the hepatitis B virus core (HBc) total antibodies test result is positive, then anti-HBc IgM testing is performed at an additional charge.
Limitations
This assay has not been licensed by the US FDA for the screening of blood, plasma, and tissue donors. False-positive results can occur due to interference by biotin supplements, antibodies to immunological components, or other factors. Results should be assessed alongside the patient's medical history and other findings. The Elecsys anti-HBc II immunoassay cannot be used interchangeably with other manufacturers' assay methods.
FDA ApprovedNew York Approved
Methodology
Immunoassay (ECLIA)
Biomarkers
LOINC Codes
- 13952-7
- 13952-7
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.7 mL
Minimum Volume
0.6 mL
Container
Serum gel (red-top tubes are not acceptable), Submission Container/Tube: Plastic vial
Collection Instructions
Centrifuge blood collection tube per manufacturer's instructions and aliquot within 2 hours of collection. Aliquot serum into a plastic vial.
Patient Preparation
Patient should not take multivitamins or dietary supplements containing biotin (vitamin B7) for 24 hours before specimen collection.
Causes for Rejection
Gross hemolysis, gross lipemia, gross icterus, and heat-inactivated specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |
| Refrigerated | 6 days |
| Frozen | 90 days |