Human Epididymis Protein 4, Serum
Use
Human Epididymis Protein 4 (HE4) is useful for aiding in monitoring patients with treated epithelial ovarian cancer for recurrence or progression. It is not recommended for use as a screening test for ovarian cancer, but it complements CA 125 measurement in post-therapy monitoring of ovarian cancer patients.
Special Instructions
Not provided.
Limitations
Results cannot be interpreted as absolute evidence of malignant ovarian disease presence or absence, as mild elevations might be present in benign gynecologic conditions and other diseases. The test should be used in conjunction with other clinical methods. The presence of certain antibodies may interfere in some immunoassays, so laboratory should be notified if results do not correlate with clinical presentation.
FDA ApprovedNew York Approved
Methodology
Immunoassay (ECLIA)
Biomarkers
HE4
Protein
LOINC Codes
- 55180-4 - HE4 SerPl-sCnc
- 55180-4 - HE4 SerPl-sCnc
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.75 mL
Container
Plastic vial
Collection Instructions
Centrifuge and aliquot serum into a plastic vial.
Patient Preparation
For 12 hours before specimen collection, patient should not take multivitamins or dietary supplements containing biotin (vitamin B7).
Causes for Rejection
Gross hemolysis
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 7 days |
| Frozen | 84 days |