Immunoglobulin A (IgA), Serum
Use
The Immunoglobulin A (IgA) Serum test is used for the detection or monitoring of IgA monoclonal gammopathies and IgA-related immune deficiencies. IgA is an important protein in the immune system and its levels are indicative of the humoral immune status. The test helps in diagnosing primary immunodeficiency conditions and in monitoring various diseases such as advanced malignant tumors and lymphatic leukemia. Elevated levels of IgA are associated with monoclonal gammopathies like multiple myeloma, primary systemic amyloidosis, and other related disorders.
Special Instructions
Cascade testing is recommended for celiac disease, ensuring an algorithmic approach to testing. Algorithms available include 'Celiac Disease Comprehensive Cascade Test Algorithm', 'Celiac Disease Diagnostic Testing Algorithm', and others. Specific test ordering guidance is available depending on the clinical context, e.g., patients adhering to a gluten-free diet are directed to the 'Celiac Disease Gluten-Free Cascade'. For electronic orders, complete and provide the 'Gastroenterology and Hepatology Test Request' form with the specimen.
Limitations
Results from different assay manufacturers or methods may not be comparable. In cases of lipemic sera, quantitation by nephelometry may not be possible due to light scattering, resulting in variable data. Electrophoresis is needed for determining the nature of an elevated immunoglobulin class as either polyclonal or monoclonal. Immunofixation may be necessary to characterize a monoclonal protein. Furthermore, changes in quantitation could reflect changes in the background immunoglobulins.
FDA ApprovedNew York Approved
Methodology
Automated Analyzer (Nephelometry)
Biomarkers
LOINC Codes
- 2458-8
- 2458-8
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
Serum gel (preferred) or Red top accepted. Submission in a Plastic vial.
Collection Instructions
Centrifuge and aliquot serum into a plastic vial.
Storage Instructions
Refrigerated preferred. Suitable at ambient for 14 days, refrigerated for 28 days, and frozen for 28 days.
Causes for Rejection
Gross lipemia
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 28 days |
| Frozen | 28 days |