Immunoglobulin G (IgG), Serum
Use
The Immunoglobulin G (IgG), Serum test is useful in detecting or monitoring IgG monoclonal gammopathies and immune deficiencies. Quantitative determination of immunoglobulins like IgG provides vital information on the humoral immune status, as these are produced by plasma cells during the immune response to antigens. Decreased IgG levels may signify primary immunodeficiency conditions or secondary immune insufficiencies often seen in various malignancies or diseases such as lymphatic leukemia and multiple myeloma. Monoclonal immunoglobulin proliferations detected in conditions like Waldenstrom disease and heavy-chain disease necessitate detailed diagnostic investigations beyond quantitative determination.
Special Instructions
Not provided.
Limitations
Quantitative immunoglobulin analysis may not be possible in the presence of lipemia due to variable light scattering, affecting nephelometric measurements. Electrophoresis and immunofixation are typically required to classify elevated immunoglobulin as polyclonal or monoclonal. For monoclonal proteins with polyclonal backgrounds, changes in quantitation reflect changes in the background immunoglobulins, necessitating serum protein electrophoresis for accurate monitoring. Comparability of results can vary across different assay manufacturers or methods.
FDA ApprovedNew York Approved
Methodology
Automated Analyzer (Nephelometry)
Biomarkers
Immunoglobulin G (IgG)
Analyte
LOINC Codes
- 2465-3 - IgG SerPl-mCnc
- 2465-3 - IgG SerPl-mCnc
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
Plastic vial
Collection Instructions
Centrifuge and aliquot serum into a plastic vial.
Causes for Rejection
Gross lipemia
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 28 days |
| Frozen | 28 days |