Immunoglobulins (IgG, IgA, and IgM), Serum
Use
This test is useful for detecting or monitoring monoclonal gammopathies and immune deficiencies. Quantitative determination of immunoglobulins provides important information on the humoral immune status. Increased levels may indicate polyclonal or monoclonal immunoglobulin proliferation in conditions such as hepatic disease, connective tissue diseases, infections, and monoclonal gammopathies. Decreased levels can be found in primary immunodeficiency conditions and secondary immune insufficiencies, including advanced malignant tumors and lymphatic leukemia.
Special Instructions
Not provided.
Limitations
Electrophoresis is often required to accurately interpret elevated immunoglobulin levels as polyclonal versus monoclonal. Immunofixation is needed to characterize monoclonal proteins. Results obtained from different assay manufacturers or methods may not be comparable. Lipemic sera can interfere with nephelometric analysis due to light scattering properties, affecting test results.
FDA ApprovedNew York Approved
Methodology
Immunoassay (Nephelometry)
Biomarkers
IgA
ProteinIgG
ProteinIgM
Protein
LOINC Codes
- 34550-4 - Immunoglobulin Pnl Ser-mCnc
- 2458-8 - IgA SerPl-mCnc
- 2465-3 - IgG SerPl-mCnc
- 2472-9 - IgM SerPl-mCnc
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
Plastic vial
Collection Instructions
Centrifuge and aliquot serum into a plastic vial.
Storage Instructions
Refrigerate for up to 28 days. Can be stored ambient for 14 days or frozen for 28 days.
Causes for Rejection
Gross lipemia
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 28 days |
| Frozen | 28 days |