Interferon Regulatory Factor 8 (IRF8) Immunostain, Technical Component Only
Use
Identification of monoblasts in acute monoblastic/monocytic leukemia and chronic myelomonocytic leukemia. Interferon regulatory factor 8 (IRF8) is a marker for monocytic and dendritic cell progenitors. Expression of IRF8 is also observed in blastic plasmacytoid dendritic cell neoplasm and may be useful to distinguish classic Hodgkin lymphoma and anaplastic large cell lymphoma.
Special Instructions
This test includes only technical performance of the stain; no pathologist interpretation is provided. Technical component only stains should not be ordered with PATHC / Pathology Consultation. If ordered with PATHC, the technical component stains will be canceled.
Limitations
Age of a cut paraffin section can affect immunoreactivity. Stability thresholds vary widely among published literature and are antigen dependent. Best practice is for paraffin sections to be cut within 6 weeks. The charge of glass slides can be affected by environmental factors and subsequently may alter slide staining. Sending unsuitable glass slides can result in inconsistent staining due to poor slide surface chemistry.
FDA ApprovedNew York Approved
Methodology
Immunoassay (IHC)
Biomarkers
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Immunostain Technical Only Envelope
Storage Instructions
Ambient (preferred) or Refrigerated.
Causes for Rejection
Wet/frozen tissue; Cytology smears; Nonformalin fixed tissue; Nonparaffin embedded tissue; Noncharged slides; ProbeOn slides; Snowcoat slides